If you’re researching wrinkle-relaxing injectables, you’ve likely seen Botox, Dysport, and Letybo mentioned together. While they are often grouped under the same category, they are not interchangeable in practice.

At Denver Dream Med Spa, neuromodulator selection is based on facial anatomy, muscle dynamics, and aesthetic goals — not trends or brand names.

This guide explains the real differences so you can make an informed decision.

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What Are Neuromodulators?

Botox, Dysport, and Letybo are all botulinum toxin type A neuromodulators. They work by temporarily relaxing targeted facial muscles that cause dynamic wrinkles — lines that form with expression.

They are commonly used to treat:

  • Forehead lines

  • Frown lines (glabellar “11s”)

  • Crow’s feet

All three are FDA-approved, well-studied, and safe when administered correctly.

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The Differences That Actually Matter

1. Diffusion & Precision

  • Botox offers highly controlled placement and is often preferred for smaller or more delicate areas.

  • Dysport diffuses slightly more, making it effective for broader muscle groups like the forehead.

  • Letybo is often described as smooth and balanced, with even muscle relaxation.

Diffusion is not good or bad — it must match the anatomy being treated.

2. Onset of Results

  • Botox: 3–7 days

  • Dysport: 2–5 days (often faster onset)

  • Letybo: Similar to Dysport, with some patients noticing early softening

Faster onset can be helpful before events, but does not indicate superiority.

3. Look & Feel

  • Botox tends to feel firmer and more targeted

  • Dysport and Letybo often feel softer and more blended

These differences are subtle but meaningful when injected by experienced providers.

4. Longevity

All three typically last 3–4 months, depending on:

  • Muscle strength

  • Dosage

  • Metabolism

  • Injection technique

No neuromodulator permanently stops muscle movement.

Which Neuromodulator Is “Best”?

There is no universal best.

You may prefer:

  • Botox for precise correction and predictability

  • Dysport for smoother diffusion in larger areas

  • Letybo for balanced relaxation and newer formulation options

👉 Injector assessment matters far more than product choice.

Why Injector Skill Is the Deciding Factor

Poor outcomes are almost never caused by the neuromodulator itself. They are caused by:

  • Inaccurate dosing

  • Poor placement

  • Failure to assess facial movement

At Denver Dream Med Spa, we assess:

  • How your face moves at rest and with expression

  • Muscle strength and asymmetry

  • Gender-specific anatomy

  • Long-term aging patterns

Only then do we select the appropriate product.

👉 Schedule a Neuromodulator Consultation in Denver

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